Autoreactive B Cells Escape Clonal Deletion by Expressing Multiple Antigen Receptors
نویسندگان
چکیده
منابع مشابه
Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors.
IgH and L chain transgenes encoding a phosphocholine (PC)-specific Ig receptor were introduced into recombinase-activating gene (Rag-2-/-) knockout mice. The PC-specific B cells that developed behaved like known autoreactive lymphocytes. They were 1) developmentally arrested in the bone marrow, 2) unable to secrete Ab, 3) able to escape clonal deletion and develop into B1 B cells in the periton...
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Despite negative selection in the thymus, significant numbers of autoreactive T cells still escape to the periphery and cause autoimmune diseases when immune regulation goes awry. It is largely unknown how these T cells escape clonal deletion. In this study, we report that CD24 deficiency caused deletion of autoreactive T cells that normally escape negative selection. Restoration of CD24 expres...
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To study the fate of developing B cells in the presence and absence of the autoantigens to which they react, chimeric mice were constructed by injecting bone marrow cells from mice transgenic for rearranged immunoglobulin genes encoding an anti-H-2Kk antibody into irradiated recipients that did or did not express the H-2Kk antigen. In the presence of H-2Kk, the anti-H-2Kk-specific B cells were ...
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B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cel...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2000
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.164.8.4111